Cerebral ischemia induces the aggregation of proteins linked to neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.
The maintenance of protein solubility is a fundamental aspect of cellular homeostasis because protein aggregation is associated with a wide variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and aggregate, and widespread aggregation can occur in living systems under stress or aging. A crucial question in this context is why only certain protei...
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With the assistance of proteins called chaperones, newly translated proteins fold into the three-dimensional shapes that are critical to their function. When proteins fold abnormally or become unstable, the consequences can be dire for cells, particularly neurons, which are exquisitely sensitive to the accumulation of misfolded proteins. Many neurodegenerative diseases, like Parkinson’s and Cre...
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Proteins and peptides are essential complex macromolecules of organisms and participate in actually every process within cells. Three dimensional structures of proteins play a critical role for biological functions. Therefore, they must be properly folded for performing these functions. Three dimensional structures are determined by composition of amino acid se‐ quence. In addition to hydrophob...
متن کاملAMPAergic mechanisms linked to cerebral ischemia
Brain ischemia is the most common cause of invalidity in adults and consequently of death throughout the world. This phenomenon occurs when blood flow is reduced or interrupted in the various brain districts leading to oxygen and glucose deprivation (OGD), which by triggering an intricate succession of biochemical plus molecular events such as an increased production of oxidized and misfolded p...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-21063-z